Ontology highlight
ABSTRACT:
SUBMITTER: Sheikh F
PROVIDER: S-EPMC2575833 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Sheikh Farah F Raskin Anna A Chu Pao-Hsien PH Lange Stephan S Domenighetti Andrea A AA Zheng Ming M Liang Xingqun X Zhang Tong T Yajima Toshitaka T Gu Yusu Y Dalton Nancy D ND Mahata Sushil K SK Dorn Gerald W GW Brown Joan Heller JH Peterson Kirk L KL Omens Jeffrey H JH McCulloch Andrew D AD Chen Ju J
The Journal of clinical investigation 20081103 12
The response of cardiomyocytes to biomechanical stress can determine the pathophysiology of hypertrophic cardiac disease, and targeting the pathways regulating these responses is a therapeutic goal. However, little is known about how biomechanical stress is sensed by the cardiomyocyte sarcomere to transduce intracellular hypertrophic signals or how the dysfunction of these pathways may lead to disease. Here, we found that four-and-a-half LIM domains 1 (FHL1) is part of a complex within the cardi ...[more]