Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling.

ABSTRACT: Changes in gene expression associated with skeletal muscle atrophy due to aging are distinct from those due to disuse, suggesting that the response of old muscle to inactivity may be altered. The goal of this study was to identify changes in muscle gene expression that may contribute to loss of adaptability of old muscle. Muscle atrophy was induced in young adult (6-mo) and old (32-mo) male Brown Norway/F344 rats by 2 wk of hindlimb suspension (HS), and soleus muscles were analyzed by cDNA microarrays. Overall, similar changes in gene expression with HS were observed in young and old muscles for genes encoding proteins involved in protein folding (heat shock proteins), muscle structure, and contraction, extracellular matrix, and nucleic acid binding. More genes encoding transport and recep

SUBMITTER: Dupont-Versteegden EE 

PROVIDER: S-EPMC2576097 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature