Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.

ABSTRACT: The existence and maintenance of biological rhythms linked to the 24-h light-dark cycle are essential to the health and functioning of an organism. Although much is known concerning central clock mechanisms, much less is known about control in peripheral tissues. In this study, circadian regulation of gene expression was examined in rat skeletal muscle. A rich time series involving 54 animals euthanized at 18 distinct time points within the 24-h cycle was performed, and mRNA expression in gastrocnemius muscles was examined using Affymetrix gene arrays. Data mining identified 109 genes that were expressed rhythmically, which could be grouped into eight distinct temporal clusters within the 24-h cycle. These genes were placed into 11 functional categories, which were examined within the cont

SUBMITTER: Almon RR 

PROVIDER: S-EPMC2576101 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature