Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea.

ABSTRACT:

Background

Astroviruses infect a variety of mammals and birds and are causative agents of diarrhea in humans and other animal hosts. We have previously described the identification of several sequence fragments with limited sequence identity to known astroviruses in a stool specimen obtained from a child with acute diarrhea, suggesting that a novel virus was present.

Results

In this study, the complete genome of this novel virus isolate was sequenced and analyzed. The overall genome organization of this virus paralleled that of known astroviruses, with 3 open reading frames identified. Phylogenetic analysis of the ORFs indicated that this virus is highly divergent from all previously described animal and human astroviruses. Molecular features that are highly conserved in hum

SUBMITTER: Finkbeiner SR 

PROVIDER: S-EPMC2576171 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature