Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.

ABSTRACT:

Background

The maternal contribution of transcripts and proteins supplied to the zygote is crucial for the progression from a gametic to an embryonic control of preimplantation development. Here we compared the transcriptional profiles of two types of mouse MII oocytes, one which is developmentally competent (MIISN oocyte), the other that ceases development at the 2-cell stage (MIINSN oocyte), with the aim of identifying genes and gene expression networks whose misregulated expression would contribute to a reduced developmental competence.

Results

We report that: 1) the transcription factor Oct-4 is absent in MIINSN oocytes, accounting for 2) the down-regulation of Stella, a maternal-effect factor required for the oocyte-to-embryo transition and of which Oct-4 is a positive

SUBMITTER: Zuccotti M 

PROVIDER: S-EPMC2576189 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature