Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria.

ABSTRACT:

Background

There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with different clinical outcomes. The population genetic structures of P. falciparum isolates from patients with either severe or uncomplicated malaria were examined.

Methods

Twelve microsatellite DNA loci from P. falciparum were used to assess the population genetic structures of 50 isolates (i.e., 25 isolates from patients with severe malaria and 25 from patients with uncomplicated malaria) collected in the Thai-Myanmar border area between 2002 and 2005.

Results

Genetic diversity and effective population sizes were greater in the uncomplicated malaria group th

SUBMITTER: Susomboon P 

PROVIDER: S-EPMC2576340 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature