Canine fibroblast growth factor receptor 3 sequence is conserved across dogs of divergent skeletal size.

ABSTRACT:

Background

Fibroblast growth factor receptor 3 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of linear bone elongation. Activating mutations severely limit bone growth, resulting in dwarfism, while inactivating mutations significantly enhance bone elongation and overall skeletal size. Domesticated dogs exhibit the greatest skeletal size diversity of any species and, given the regulatory role of FGFR3 on growth plate proliferation, we asked whether sequence differences in FGFR3 could account for some of the size differences.

Methods

All exons, the promoter region, and 60 bp of the 3' flanking region of the canine FGFR3 gene were sequenced for nine different dog breeds representing a spectrum of skeletal size. The resultant s

SUBMITTER: Smith LB 

PROVIDER: S-EPMC2576350 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature