Intergenic and genic sequence lengths have opposite relationships with respect to gene expression.

ABSTRACT: Eukaryotic genomes are mostly composed of noncoding DNA whose role is still poorly understood. Studies in several organisms have shown correlations between the length of the intergenic and genic sequences of a gene and the expression of its corresponding mRNA transcript. Some studies have found a positive relationship between intergenic sequence length and expression diversity between tissues, and concluded that genes under greater regulatory control require more regulatory information in their intergenic sequences. Other reports found a negative relationship between expression level and gene length and the interpretation was that there is selection pressure for highly expressed genes to remain small. However, a correlation between gene sequence length and expression diversity, opposite to

SUBMITTER: Colinas J 

PROVIDER: S-EPMC2576458 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature