Metagenomic screening for bleomycin resistance genes.

ABSTRACT: A metagenomic library of activated sludge was screened for bleomycin resistance genes. Two genes were identified that differed greatly from each other, from the genes of bleomycin-producing actinomycetes, and from those of clinical isolates. Therefore, the nonclinical environment is a rich reservoir of new resistance elements, and metagenomics can be used to sample the resistome rapidly.

SUBMITTER: Mori T 

PROVIDER: S-EPMC2576686 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature