A New Antimalarial Polyether from a Marine Streptomyces sp. H668.

ABSTRACT: The antimalarial guided fractionation of the culture of marine Streptomyces sp. strain H668 led to the isolation of a new polyether metabolite. The structure was determined by comprehensive NMR and MS assignments. This new metabolite showed in vitro antimalarial activity against both the chloroquine-susceptible (D6) and -resistant (W2) clones of Plasmodium falciparum, without cytotoxicity to normal cells (Vero) making it a promising first lead from this marine bacterium.

SUBMITTER: Na M 

PROVIDER: S-EPMC2577051 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature