Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors.

ABSTRACT: During pancreas development, transcription factors play critical roles in exocrine and endocrine differentiation. Transcriptional regulation in eukaryotes occurs within chromatin and is influenced by posttranslational histone modifications (e.g., acetylation) involving histone deacetylases (HDACs). Here, we show that HDAC expression and activity are developmentally regulated in the embryonic rat pancreas. We discovered that pancreatic treatment with different HDAC inhibitors (HDACi) modified the timing and determination of pancreatic cell fate. HDACi modified the exocrine lineage via abolition and enhancement of acinar and ductal differentiation, respectively. Importantly, HDACi treatment promoted the NGN3 proendocrine lineage, leading to an increased pool of endocrine progenitors and modi

SUBMITTER: Haumaitre C 

PROVIDER: S-EPMC2577441 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature