Polymorphisms in the HBB gene relate to individual cardiorespiratory adaptation in response to endurance training.

ABSTRACT:

Objective

The crucial role of haemoglobin in endurance performance has been well documented. We examined whether polymorphisms in the HBB gene modified aerobic capacity.

Methods

102 recruits were trained by running 5000 m three times per week for 18 weeks. Exercise intensity progressively increased from an initial heart rate corresponding to 95% of the individual baseline ventilatory threshold during the first 10 weeks to 105% during the last 8 weeks. The phenotypes measured were running economy and VO(2)max. Running economy was determined by measuring submaximal VO(2) for 5 min at a constant running speed of 12 km.h(-1) and VO(2)max was obtained during an incremental test to exhaustion. Genomic DNA was extracted from white cells of peripheral blood and the -551C/T, intron2,

SUBMITTER: He Z 

PROVIDER: S-EPMC2577474 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature