A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells.

ABSTRACT:

Background

Neural crest progenitors arise as epithelial cells and then undergo a process of epithelial to mesenchymal transition that precedes the generation of cellular motility and subsequent migration. We aim at understanding the underlying molecular network. Along this line, possible roles of Rho GTPases that act as molecular switches to control a variety of signal transduction pathways remain virtually unexplored, as are putative interactions between Rho proteins and additional known components of this cascade.

Results

We investigated the role of Rho/Rock signaling in neural crest delamination. Active RhoA and RhoB are expressed in the membrane of epithelial progenitors and are downregulated upon delamination. In vivo loss-of-function of RhoA or RhoB or of overall Rho s

SUBMITTER: Groysman M 

PROVIDER: S-EPMC2577655 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature