The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands.

ABSTRACT:

Background

The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR-10 family of plant pathogenesis-related proteins. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. In addition, determination of the Bet v 1 structure revealed the existence of a large superfamily of structurally related proteins. In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database.

Results

Structural comparisons of representative members of already known protein families structurally related to Bet v 1 with all entries of the Protein Data Bank yielded 47 structures with non-identical sequences. They were classified int

SUBMITTER: Radauer C 

PROVIDER: S-EPMC2577659 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature