Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol.

ABSTRACT:

Background

Pseudomonas aeruginosa (P. aeruginosa) is the most common opportunistic pathogen implicated in nosocomial infections and in chronic lung infections in cystic fibrosis patients. Ortho-phenylphenol (OPP) is an antimicrobial agent used as an active ingredient in several EPA registered disinfectants. Despite its widespread use, there is a paucity of information on its target molecular pathways and the cellular responses that it elucidates in bacteria in general and in P. aeruginosa in particular. An understanding of the OPP-driven gene regulation and cellular response it elicits will facilitate more effective utilization of this antimicrobial and possibly lead to the development of more effective disinfectant treatments.

Results

Herein, we performed a genome-wide tran

SUBMITTER: Nde CW 

PROVIDER: S-EPMC2577666 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature