Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations.

ABSTRACT:

Rationale

Superoxide dismutase (SOD) 3 inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate. Inherited change in SOD3 expression or function could affect lung matrix homeostasis and influence pulmonary function.

Objectives

To identify novel SOD3 polymorphisms that are associated with lung function or chronic obstructive pulmonary disease (COPD).

Methods

Resequencing of 182 individuals identified two novel polymorphisms, E1 (rs8192287) and I1 (rs8192288), in a conserved region of the SOD3 gene of potential relationship to lung function. We next genotyped 9,093 individuals from the Copenhagen City Heart Study for the polymorphisms and recorded spirometry, and admissions and deaths due to COPD during 26-year follow-up. Fi

SUBMITTER: Dahl M 

PROVIDER: S-EPMC2577726 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature