Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania.

ABSTRACT:

Background

At excitatory synapses, glutamate released from neurons is taken up by glial cells and converted to glutamine, which is cycled back to neurons. Alterations in this system are believed to play a role in the pathophysiology of bipolar disorder, but they have not been characterized in vivo. We examined the glutamine/glutamate ratio and levels of other metabolites in acute mania and schizophrenia in this exploratory study.

Methods

Data were obtained from 2 x 2 x 2 cm voxels in the anterior cingulate cortex (ACC) and parieto-occipital cortex (POC) using two-dimensional J-resolved proton magnetic resonance spectroscopy at 4 Tesla and analyzed using LCModel. Fifteen bipolar disorder patients with acute mania and 17 schizophrenia patients with acute psychosis were recruit

SUBMITTER: Ongur D 

PROVIDER: S-EPMC2577764 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature