Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models.

ABSTRACT:

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Liver regeneration is impaired following partial hepatectomy (PH) in mice with genetic obesity and hepatic steatosis and also in wild-type mice fed a high-fat diet. These findings contrast with other data showing that liver regeneration is impaired in mice in which hepatic lipid accumulation is suppressed by either pharmacologic leptin administration or by disrupted glucocorticoid signaling. These latter findings suggest that hepatic steatosis may actually be required for normal liver regeneration. We have reexamined this relationship using several murine models of altered hepatic lipid metabolism. Liver fatty acid (FA) binding protein knockout mice manifested reduced hepatic triglyceride (TG) content compared to controls, with no effect on liver regeneration or hepatocy

SUBMITTER: Newberry EP 

PROVIDER: S-EPMC2577767 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature