Expression profiling of human glial precursors.

ABSTRACT:

Background

We have generated gene expression databases for human glial precursors, neuronal precursors, astrocyte precursors and neural stem cells and focused on comparing the profile of glial precursors with that of other populations.

Results

A total of 14 samples were analyzed. Each population, previously distinguished from each other by immunocytochemical analysis of cell surface markers, expressed genes related to their key differentiation pathways. For the glial precursor cell population, we identified 458 genes that were uniquely expressed. Expression of a subset of these individual genes was validated by RT-PCR. We also report genes encoding cell surface markers that may be useful for identification and purification of human glial precursor populations.

Conclusion<

SUBMITTER: Campanelli JT 

PROVIDER: S-EPMC2579429 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature