Thyroid hormone components are expressed in three sequential waves during development of the chick retina.

ABSTRACT:

Background

Thyroid hormone (TH) is an important developmental regulator in many tissues, including the retina. TH is activated locally via deiodinase 2 (Dio2), and it is destroyed by deiodinase 3 (Dio3). The TH receptors, TRa and TRb, mediate TH activity through hormone and DNA binding, and interactions with transcription regulators.

Results

In the current work, the expression of these TH components was examined in the chick retina over time. Three waves of expression were characterized and found to be correlated with critical developmental events. The first wave occurred as progenitor cells began to make photoreceptors, the second as some cell types adopted a more mature location and differentiation state, and the third as Müller glia were generated. The cell types expressi

SUBMITTER: Trimarchi JM 

PROVIDER: S-EPMC2579430 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature