Identification of hot-spot residues in protein-protein interactions by computational docking.

ABSTRACT:

Background

The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the structural prediction of protein-protein binding mode, and the identification of the relevant residues for the interaction (so called 'hot-spots'). These hot-spot residues have high interest since they are considered one of the possible ways of disrupting a protein-protein interaction. Unfortunately, large-scale experimental measurement of residue contribution to the binding energy, based on alanine-scanning experiments, is costly and thus data is fairly limited. Recent computational approaches for hot-spot prediction have been reported, but they usually require the structure of the complex.

Results

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SUBMITTER: Grosdidier S 

PROVIDER: S-EPMC2579439 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature