Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control.

ABSTRACT:

Background

The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls important physiological processes. Specific sets of membrane proteins involved in sensing the extracellular milieu are concentrated within cilia, including G protein coupled receptors (GPCRs). Most GPCRs are regulated by beta-arrestins, betaarr1 and betaarr2, which control both their signalling and endocytosis, suggesting that betaarrs may also function at primary cilium.

Methodology/principal findings

In cycling cells, betaarr2 was observed at the centrosome, at the proximal region of the centrioles, in a microtubule independent manner. However, betaarr2 did not appear to be involved in classical centrosome

SUBMITTER: Molla-Herman A 

PROVIDER: S-EPMC2579577 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature