Estradiol rates of change in relation to the final menstrual period in a population-based cohort of women.

ABSTRACT:

Context/objective

The aim was to characterize rates of change in serum estradiol (E2) levels across the menopausal transition and into early postmenopause.

Setting/participants

We studied the Michigan Bone Health and Metabolism Study cohort of 629 women with median age of 38 yr (interquartile range, 7) at the 1992-1993 baseline with annual assessment of E2 levels over the subsequent 15-yr period. DESIGN/MAIN OUTCOME MEASURES: The purpose was to describe patterns of acceleration/deceleration in (log)E2 rates of change before and after the final menstrual period (FMP) using nonparametric and piecewise regression modeling.

Results

Between -10 to -2 yr to the FMP, mean fitted serum E2 population values were relatively stable. The 95% confidence bands around the slight inc

SUBMITTER: Sowers MR 

PROVIDER: S-EPMC2579642 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature