A genome-wide linkage scan for age at menarche in three populations of European descent.

ABSTRACT:

Context

Age at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes.

Objective

The objective of the study was to identify genetic loci influencing variation in AAM in large population-based samples from three countries.

Design/participants

Recalled AAM data were collected from 13,697 individuals and 4,899 pseudoindependent sister-pairs from three different populations (Australia, The Netherlands, and the United Kingdom) by mailed questionnaire or interview. Genome-wide variance components linkage analysis was implemented on each sample individually and in combination.

Results

The mean, sd, and heritability of AAM across the

SUBMITTER: Anderson CA 

PROVIDER: S-EPMC2579643 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature