Assessment of coronary heart disease risk by combined analysis of coagulation factors.

ABSTRACT:

Objective

Prospective studies have reported a positive association of coagulation factors with risk of coronary heart disease (CHD). It is unclear whether these coagulation factors interact.

Methods and results

Using a prospective case-cohort design, we analyzed by Cox proportional hazard regression interactions between soluble thrombomodulin (sTM) and fibrinogen, factor VIII (FVIII), FVII, or plasminogen activator inhibitor-1 (PAI-1) in 410 CHD cases and 721 non-cases from the Atherosclerosis Risk in Communities (ARIC). There was a significant interaction between sTM and fibrinogen (p=0.027). We next assessed risk ratios (RR) by combined tertile analysis. Combined analysis revealed that being in the upper sTM tertile counteracted the CHD risk imposed by higher fibrinogen wh

SUBMITTER: Aleksic N 

PROVIDER: S-EPMC2579959 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature