Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli.

ABSTRACT: We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis.

SUBMITTER: Inoue A 

PROVIDER: S-EPMC2580715 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature