Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.

ABSTRACT: The mammalian kidney consists of an array of tubules connected to a ductal system that collectively function to control water/salt balance and to remove waste from the organisms' circulatory system. During mammalian embryogenesis, three kidney structures form within the intermediate mesoderm. The two most anterior structures, the pronephros and the mesonephros, are transitory and largely non-functional, while the most posterior, the metanephros, persists as the adult kidney. We have explored the mechanisms underlying regional specific differentiation of the kidney forming mesoderm. Previous studies have shown a requirement for Hox11 paralogs (Hoxa11, Hoxc11 and Hoxd11) in metanephric development. Mice lacking all Hox11 activity fail to form metanephric kidney structures. We demonstrate tha

SUBMITTER: Mugford JW 

PROVIDER: S-EPMC2580739 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature