Predicting the order in which contacts are broken during single molecule protein stretching experiments.

ABSTRACT: We combine two methods to enable the prediction of the order in which contacts are broken under external stretching forces in single molecule experiments. These two methods are Gō-like models and elastic network models. The Gō-like models have shown remarkable success in representing many aspects of protein behavior, including the reproduction of experimental data obtained from atomic force microscopy. The simple elastic network models are often used successfully to predict the fluctuations of residues around their mean positions, comparing favorably with the experimentally measured crystallographic B-factors. The behavior of biomolecules under external forces has been demonstrated to depend principally on their elastic properties and the overall shape of their structure. We have studied i

SUBMITTER: Sulkowska JI 

PROVIDER: S-EPMC2580773 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature