Dynamic changes in protein functional linkage networks revealed by integration with gene expression data.

ABSTRACT: Response of cells to changing environmental conditions is governed by the dynamics of intricate biomolecular interactions. It may be reasonable to assume, proteins being the dominant macromolecules that carry out routine cellular functions, that understanding the dynamics of protein:protein interactions might yield useful insights into the cellular responses. The large-scale protein interaction data sets are, however, unable to capture the changes in the profile of protein:protein interactions. In order to understand how these interactions change dynamically, we have constructed conditional protein linkages for Escherichia coli by integrating functional linkages and gene expression information. As a case study, we have chosen to analyze UV exposure in wild-type and SOS deficient E. coli at

SUBMITTER: Hegde SR 

PROVIDER: S-EPMC2580820 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature