Relationship between physical activity level, telomere length, and telomerase activity.

ABSTRACT:

Purpose

The purpose of this study was to examine the relationship of exercise energy expenditure (EEE) with both telomere length and telomerase activity in addition to accounting for hTERT C-1327T promoter genotype.

Methods

Sixty-nine (n = 34 males; n = 35 females) participants 50-70 yr were assessed for weekly EEE level using the Yale Physical Activity Survey. Lifetime consistency of EEE was also determined. Subjects were recruited across a large range of EEE levels and separated into quartiles: 0-990, 991-2340, 2341-3540, and >3541 kcal x wk(-1). Relative telomere length and telomerase activity were measured in peripheral blood mononuclear cells (PBMC).

Results

The second EEE quartile exhibited significantly longer telomere lengths [1.12 +/- 0.03 relative units (RU)

SUBMITTER: Ludlow AT 

PROVIDER: S-EPMC2581416 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature