Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers.

ABSTRACT: Phenotypes related to both nicotine dependence and ability to successfully quit smoking display substantial heritabilities in classical and molecular genetic studies. Twin studies suggest that some genetic components for dependence overlap with genetic components of ability to quit, but that many components do not overlap. Initial genome-wide association (GWA) studies have demonstrated haplotypes that distinguish nicotine-dependent from nondependent smokers. These haplotypes overlap partially with those that distinguish individuals who successfully quit smoking from those who were not able to quit smoking in clinical trials for smoking cessation. We now report novel genome-wide association results from National Institutes of Health research volunteers who reported smoking histories, sympto

SUBMITTER: Drgon T 

PROVIDER: S-EPMC2581605 | biostudies-literature | 2009 Jan-Feb

REPOSITORIES: biostudies-literature