Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway.

ABSTRACT: Alterations in DNA repair genes have been shown to cause a reduction in host DNA repair capacity and may influence host susceptibility to carcinogenesis. The double-strand break repair is a major DNA-repair pathway. This study tested the hypothesis that common sequence variants of the double-strand break pathway genes predispose susceptible individuals to an increased risk for renal cell carcinoma. Toward this end, we evaluated the associations of 13 single-nucleotide polymorphisms in 10 candidate genes involved in the double-strand break pathway with renal cell carcinoma risk in a population-based case-control study that included 326 Caucasian renal cell carcinoma patients and 335 controls. Using the homozygous wild type as the reference group, we observed a significantly increased renal

SUBMITTER: Margulis V 

PROVIDER: S-EPMC2581835 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature