Identification of single-nucleotide polymorphism in the progesterone receptor gene and its association with reproductive traits in rabbits.

ABSTRACT: A total of 598 F2 does from a cross between the high and low lines selected divergently for uterine capacity during 10 generations were used in a candidate gene analysis. The presence of major genes affecting the number of implanted embryos and uterine capacity has been suggested in lines divergently selected for uterine capacity. Uterine capacity is a main component of litter size. The progesterone receptor gene was tested as a candidate gene to determine whether polymorphisms explain differences in litter size and its components. Fragments of the promoter region and exons 1-8 were amplified and sequenced. One SNP was found in the promoter region, 2464G>A, three SNPs in the 5'-UTR exon 1, and a silence SNP in exon 7. The first four SNPs were segregated in two haplotypes. The allele G foun

SUBMITTER: Peiro R 

PROVIDER: S-EPMC2581969 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature