Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.

ABSTRACT: Adiposity status and change are potential risk factors for Alzheimer's disease (AD). The authors used data on 2,322 participants in the Baltimore Longitudinal Study of Aging to analyze the relation between AD incidence and adiposity in Cox proportional hazards models, with adjustment for sociodemographic factors and smoking status. Body mass index (BMI; weight (kg)/height (m)(2)) and waist circumference at specific ages were predicted by empirical Bayes estimators from mixed-effects regression models. After a median of 23.4 years of follow-up between 1958 and 2006, 187 participants developed AD. Among men, being underweight (BMI

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC2582058 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature