Enhanced retention of the alpha-particle-emitting daughters of Actinium-225 by liposome carriers.

ABSTRACT: Targeted alpha-particle emitters hold great promise as therapeutics for micrometastatic disease. Because of their high energy deposition and short range, tumor targeted alpha-particles can result in high cancer-cell killing with minimal normal-tissue irradiation. Actinium-225 is a potential generator for alpha-particle therapy: it decays with a 10-day half-life and generates three alpha-particle-emitting daughters. Retention of (225)Ac daughters at the target increases efficacy; escape and distribution throughout the body increases toxicity. During circulation, molecular carriers conjugated to (225)Ac cannot retain any of the daughters. We previously proposed liposomal encapsulation of (225)Ac to retain the daughters, whose retention was shown to be liposome-size dependent. However, daught

SUBMITTER: Sofou S 

PROVIDER: S-EPMC2582153 | biostudies-literature | 2007 Nov-Dec

REPOSITORIES: biostudies-literature