Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.

ABSTRACT:

Context

Although the timing of puberty is a highly heritable trait, little is known about the genes that regulate pubertal timing in the general population. Several genes have been identified that, when mutated, cause disorders of delayed or absent puberty such as hypogonadotropic hypogonadism (HH).

Objective

Because severe variants in HH-related genes cause a severe puberty phenotype, we hypothesized that common subtle variation in these genes could contribute to the population variation in pubertal timing.

Design

We assessed common genetic variation in 10 HH-related genes in 1801 women from the Hawaii and Los Angeles Multiethnic Cohort with either early (age<11 yr) or late (age>14 yr) menarche and in other replication samples. In addition to these common variants, w

SUBMITTER: Gajdos ZK 

PROVIDER: S-EPMC2582573 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature