A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population.

ABSTRACT:

Context

A number of genome-wide scans of stature have been reported previously, but with inconsistent results. The inconsistency may be partly due to differential population characteristics and gender- and/or age-specific effects on this trait.

Objective

This study aimed to identify the quantitative trait loci (QTLs) underlying the variation of stature in Chinese population, and to evaluate age- and gender-specific linkage for stature.

Methods

We conducted a large-scale, genome-wide linkage scan using the data from three independent samples (a total of 7112 subjects from 1811 pedigrees) enrolled from the same geographical region in China. Linkage analyses were performed in the pooled samples and in subgroups defined by age (25 yr), gender, or both, using t

SUBMITTER: Hong X 

PROVIDER: S-EPMC2582574 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature