Type I IFNs play a role in early resistance, but subsequent susceptibility, to the African trypanosomes.

ABSTRACT: Macrophages express a spectrum of proinflammatory and regulatory mediators during African trypanosomiasis. Microarray analyses revealed similar profiles of induced genes in macrophages stimulated with the trypanosome soluble variant surface glycoprotein in vitro and in macrophages taken from infected mice. Genes associated with the acute phase response and with type I IFN responses were prominent components of the macrophage activation profiles expressed within 72 h in vitro and in vivo. Thus, induction of proinflammatory gene expression is a characteristic of early trypanosome infection that is driven primarily by soluble variant surface glycoprotein exposure, and it may be that IFN-alpha/beta plays a central role in regulation of early resistance to trypanosomes. To test this hypothesis,

SUBMITTER: Lopez R 

PROVIDER: S-EPMC2582636 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature