Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice.

ABSTRACT:

Rationale

Uteroglobin-related protein (UGRP) 1, which is highly expressed in the epithelial cells of the airways, has been suggested to play a role in lung inflammation.

Objectives

The aim of study was to understand the effect of overexpressed UGRP1 on lung inflammation in a mouse model of allergic airway inflammation.

Methods

Ovalbumin-sensitized and -challenged mice, a model for allergic airway inflammation, were used in conjunction with recombinant adenovirus expressing UGRP1.

Measurements and main results

We demonstrated that intranasal administration of adeno-UGRP1 successfully delivered UGRP1 to the epithelial cells of airways and markedly reduced the number of infiltrating inflammatory cells, particularly eosinophils, in lung tissue as well as the level

SUBMITTER: Chiba Y 

PROVIDER: S-EPMC2582904 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature