Effects of therapeutic ceftiofur administration to dairy cattle on Escherichia coli dynamics in the intestinal tract.

ABSTRACT: The goal of this study was to follow ceftiofur-treated and untreated cattle in a normally functioning dairy to examine enteric Escherichia coli for changes in antibiotic resistance profiles and genetic diversity. Prior to treatment, all of the bacteria cultured from the cows were susceptible to ceftiofur. Ceftiofur-resistant E. coli was only isolated from treated cows during and immediately following the cessation of treatment, and the 12 bla(CMY-2)-positive isolates clustered into two genetic groups. E. coli bacterial counts dropped significantly in the treated animals (P < 0.027), reflecting a disappearance of the antibiotic-susceptible strains. The resistant bacterial population, however, did not increase in quantity within the treated cows; levels stayed low and were overtaken by a ret

SUBMITTER: Singer RS 

PROVIDER: S-EPMC2583494 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature