The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins.

ABSTRACT: The cell wall of the human pathogen Candida glabrata governs initial host-pathogen interactions that underlie the establishment of fungal infections. With the aim of identifying species-specific features that may directly relate to its virulence, we have investigated the cell wall of C. glabrata using a multidisciplinary approach that combines microscopy imaging, biochemical studies, bioinformatics, and tandem mass spectrometry. Electron microscopy revealed a bilayered wall structure in which the outer layer is packed with mannoproteins. Biochemical studies showed that C. glabrata walls incorporate 50% more protein than Saccharomyces cerevisiae walls and, consistent with this, have a higher mannose/glucose ratio. Evidence is presented that C. glabrata walls contain glycosylphosphatidylinos

SUBMITTER: de Groot PW 

PROVIDER: S-EPMC2583536 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature