Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia.

ABSTRACT: Pneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate immune response to bacteria in the lungs would provide insight into the mechanisms used by the host to protect itself from infection. An adult mouse model of Staphylococcus aureus pneumonia was utilized to define the early events in the innate immune response and to assess the changes in the airway proteome during the first 6 h of pneumonia. S. aureus actively replicated in the lungs of mice inoculated intranasally under anesthesia to cause significant morbidity and mortality. By 6 h postinoculation, the release of proinflammatory cytokines caused effective recruitment of neutrophils to the airway. Neutrophil influx, loss of alveolar archite

SUBMITTER: Ventura CL 

PROVIDER: S-EPMC2583584 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature