Age-dependent evolution of the yeast protein interaction network suggests a limited role of gene duplication and divergence.

ABSTRACT: Proteins interact in complex protein-protein interaction (PPI) networks whose topological properties-such as scale-free topology, hierarchical modularity, and dissortativity-have suggested models of network evolution. Currently preferred models invoke preferential attachment or gene duplication and divergence to produce networks whose topology matches that observed for real PPIs, thus supporting these as likely models for network evolution. Here, we show that the interaction density and homodimeric frequency are highly protein age-dependent in real PPI networks in a manner which does not agree with these canonical models. In light of these results, we propose an alternative stochastic model, which adds each protein sequentially to a growing network in a manner analogous to protein crystal

SUBMITTER: Kim WK 

PROVIDER: S-EPMC2583957 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature