Phospholipase C beta 4 in mouse hepatocytes: rhythmic expression and cellular distribution.

ABSTRACT:

Background

Circadian regulated physiological processes have been well documented in the mammalian liver. Phospholipases are important mediators of both cytoplasmic and nuclear signaling mechanisms in hepatocytes, and despite a potentially critical role for these enzymes in regulating the temporal aspect of hepatic physiology, their involvement in the circadian liver clock has not been the subject of much investigation. The phospholipase C beta4 (PLCbeta4) enzyme is of particular interest as it has been linked to circadian clock function. In general, there is no knowledge of the role of the PLCbeta4 isozyme in mammalian hepatocytes as this is the first report of its expression in the mammalian liver.

Results

We found that in the liver of mice housed on a light:dark cycle, PLC

SUBMITTER: Klein BM 

PROVIDER: S-EPMC2583973 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature