RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes.

ABSTRACT:

Background

Naturally occurring RNAs contain numerous enzymatically altered nucleosides. Differences in RNA populations (RNomics) and pattern of RNA modifications (Modomics) depends on the organism analyzed and are two of the criteria that distinguish the three kingdoms of life. If the genomic sequences of the RNA molecules can be derived from whole genome sequence information, the modification profile cannot and requires or direct sequencing of the RNAs or predictive methods base on the presence or absence of the modifications genes.

Results

By employing a comparative genomics approach, we predicted almost all of the genes coding for the t+rRNA modification enzymes in the mesophilic moderate halophile Haloferax volcanii. These encode both guide RNAs and enzymes. Some are ort

SUBMITTER: Grosjean H 

PROVIDER: S-EPMC2584109 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature