Genomic plasticity of the immune-related Mhc class I B region in macaque species.

ABSTRACT:

Background

In sharp contrast to humans and great apes, the expanded Mhc-B region of rhesus and cynomolgus macaques is characterized by the presence of differential numbers and unique combinations of polymorphic class I B genes per haplotype. The MIB microsatellite is closely linked to the single class I B gene in human and in some great apes studied. The physical map of the Mhc of a heterozygous rhesus monkey provides unique material to analyze MIB and Mamu-B copy number variation and then allows one to decipher the compound evolutionary history of this region in primate species.

Results

In silico research pinpointed 12 MIB copies (duplicons), most of which are associated with expressed B-genes that cluster in a separate clade in the phylogenetic tree. Generic primers tested

SUBMITTER: Bonhomme M 

PROVIDER: S-EPMC2584111 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature