Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection.

ABSTRACT:

Background

Very little is known about the immunological responses of amphibians to pathogens that are causing global population declines. We used a custom microarray gene chip to characterize gene expression responses of axolotls (Ambystoma mexicanum) to an emerging viral pathogen, Ambystoma tigrinum virus (ATV).

Result

At 0, 24, 72, and 144 hours post-infection, spleen and lung samples were removed for estimation of host mRNA abundance and viral load. A total of 158 up-regulated and 105 down-regulated genes were identified across all time points using statistical and fold level criteria. The presumptive functions of these genes suggest a robust innate immune and antiviral gene expression response is initiated by A. mexicanum as early as 24 hours after ATV infection. At 24 h

SUBMITTER: Cotter JD 

PROVIDER: S-EPMC2584114 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature