Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays.

ABSTRACT:

Background

Recent studies have shown similarities between schizophrenia and bipolar disorder in phenotypes and in genotypes, and those studies have contributed to an ongoing re-evaluation of the traditional dichotomy between schizophrenia and bipolar disorder. Bipolar disorder with psychotic features may be closely related to schizophrenia and therefore, psychosis may be an alternative phenotype compared to the traditional diagnosis categories.

Methods

We performed a cross-study analysis of 7 gene expression microarrays that include both psychosis and non-psychosis subjects. These studies include over 400 microarray samples (163 individual subjects) on 3 different Affymetrix microarray platforms.

Results

We found that 110 transcripts are differentially regulated (p <

SUBMITTER: Choi KH 

PROVIDER: S-EPMC2585075 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature