Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

ABSTRACT:

Background

Sporadic colorectal cancers (CRC) are multifactorial diseases resulting from the combined effects of numerous genetic, environmental and behavioral risk factors. Genetic association studies have suggested low-penetrance alleles of extremely varied genes to be involved in susceptibility to CRC in Caucasian populations.

Methods

Through a large genetic association study based on 1023 patients with sporadic CRC and 1121 controls, we tested a panel of these low-penetrance alleles to find out whether they could determine "genotypic profiles" at risk for CRC among individuals of the French population. We examined 52 polymorphisms of 35 genes - drawn from inflammation, xenobiotic detoxification, one-carbon, insulin signaling, and DNA repair pathways - for their possible c

SUBMITTER: Kury S 

PROVIDER: S-EPMC2585099 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature