Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

ABSTRACT:

Background

Establishment and maintenance of a functional central nervous system (CNS) requires a highly orchestrated process of neural progenitor cell proliferation, cell cycle exit, and differentiation. An evolutionary conserved program consisting of Notch signalling mediated by basic Helix-Loop-Helix (bHLH) transcription factor activity is necessary for both the maintenance of neural progenitor cell character and the progression of neurogenesis; however, additional players in mammalian CNS neural specification remain largely unknown. In Drosophila we recently characterized Hamlet, a transcription factor that mediates Notch signalling and neural cell fate.

Methodology/principal findings

Hamlet is a member of the Prdm (PRDI-BF1 and RIZ homology domain containing) proto-oncog

SUBMITTER: Kinameri E 

PROVIDER: S-EPMC2585159 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature